Leveraging Sensitivity to Simplify Cannabis Analysis and Improve Robustness
To ensure consumer safety, many countries and regions set maximum residue limits (MRL), which are the highest level of a given pesticide residue legally tolerated in specified food matrix. This MRL approach has been replicated in cannabis as legalization continues to expand globally. Cannabis, however, has proven to be a challenging matrix, with chemical interferences and ionization suppression being common issues to overcome. This matrix complexity also makes sample preparation difficult and can contribute to a need for frequent mass spectrometer cleaning and maintenance. With each new generation of analytical instrumentation, however, sensitivity improvements offer the ability to leverage sample dilution to mitigate the effect of matrix on the measurement of contaminants. This talk will explore how far we can push sample dilution, while still meeting regulatory limits, to simplify sample preparation and analysis workflows, as well as improve instrument robustness.