Cannabis and Hemp Analysis -- Test for the ENTIRE California Pesticide List at once using the PerkinElmer Qsight

Jul 04, 2018

High-performance liquid chromatography tandem mass spectrometry
(LC-MS/MS) has emerged as the method of choice for pesticide and
mycotoxin analysis in cannabis. Traditionally, pesticides are screened
using two analytical instruments: GC-MS/MS and LC-MS/MS. However, most
of the studies for the two system technology approach either do not
achieve California State action-limits or require multiple time
consuming sample preparation methods. Not so with PerkinElmer’s QSight
220 Pesticide Analyzer. Utilizing a single instrument and single prep
method, our method is rapid and reliable— suitable for labs wanting to
comply with stringent regulations. The recovery of all pesticides and
mycotoxins from a cannabis matrix is consistently in the State of
California’s acceptable range of 70-120% with RSD less than 20%. This
method allows identification and quantification of all 66 pesticides and
five mycotoxins at levels well below action limits (0.005 to 0.25
µg/g). The ability to screen and quantitate the hydrophobic and
chlorinated compounds normally analyzed on a GC-MS/MS, as well as the
five mycotoxins, makes this a novel technique for the cannabis industry.
Highlights of the Turnkey Method for Pesticide and Mycotoxin Analysis:
--Analysis of all California regulated pesticides and mycotoxins on a single LC-MS/MS
--Eliminates the need for GC-MS/MS by using APCI source (APCI used for PCNB and Chlordane)
--StayClean technology addresses matrix-induced maintenance issues in the MS instrument and improves throughput
--A method with LOQs below state of California action limits that is reliable and reproducible
--Simple and fast sample preparation procedure with acceptable recoveries for all analytes)
--Dual source, ESI/APCI, removes need for two instrument platforms in a lab
application includes analysis of mycotoxins and pesticides with one
instrument (sample preparation, chromatography, and mass spectrometry)