We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie Policy

Analytical Cannabis Logo
Home > News > Psychedelics > Content Piece

Two Novel Chemical Entitities Show Early Potential for Significant Treatment Improvement in Depression

Published: Aug 11, 2022   

Complete the form below and we will email you a PDF version of "Two Novel Chemical Entitities Show Early Potential for Significant Treatment Improvement in Depression "

First Name*
Last Name*
Email Address*
Company Type*
Job Function*
Would you like to receive further email communication from Analytical Cannabis?

Analytical Cannabis Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Psilera, a biopharmaceutical company optimizing next-generation mental health treatments with a technology-enabled platform, announces promising results on two patent-pending N,N-dimethyltryptamine ("DMT") analogues, PSIL-001 and PSIL-002. Psilera's new chemical entity ("NCE") library contains promising compounds with non-hallucinogenic effects when administered at therapeutic dosages in various preclinical models.

PSIL-001 and PSIL-002 showed similar preclinical efficacy to psilacetin, a positive control, in the forced swim test depression model without hallucinations via the head twitch response. Psilacetin produces psilocin, the psychedelic active ingredient with FDA breakthrough therapy designation for treatment-resistant depression. Single doses of PSIL-001 and PSIL-002 produced rapid antidepressant effects, while most current FDA-approved antidepressants take multiple doses to show efficacy.

Repeat doses of PSIL-001 and PSIL-002 also showed improvement in learning and memory tasks statistically superior to psilacetin. These important characteristics could translate to neurodegenerative disorders like dementia and Alzheimer's disease which inspired a grant application by Psilera to study their NCEs in Alzheimer's disease.

"We are excited to see the unique results exhibited by PSIL-001 and PSIL-002," said Dr. Jackie von Salm, co-founder and CSO of Psilera. "We are finally documenting much needed evidence for our hypothesis that small, strategic chemical changes to existing psychedelic compounds can greatly reduce hallucinations while maintaining efficacy. These are just two of many NCEs in our library which could greatly impact patients suffering from neurological disorders."

This article has been republished from materials provided by Psilera. Note: material may have been edited for length and content. For further information, please contact the cited source.


Like what you just read? You can find similar content on the topic tag shown below.


Stay connected with the latest news in cannabis extraction, science and testing

Get the latest news with the FREE weekly Analytical Cannabis newsletter