Manipulating Sensory Neurons with Cannabinoids to Tackle Chronic Conditions
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GB Sciences has filed a new provisional patent application on the use of cannabis-based therapies for the manipulation of cannabis-sensitive ion channels in sensory neurons that contribute to chronic inflammatory pain conditions, peripheral neuropathy, urinary cystitis, asthma, and specific types of hearing loss.
The GB Sciences drug development team believes that these new cannabis-based treatments could well herald the dawning of ‘individualized medicines’ from the cannabis plant by re-establishing balance in each individual patient’s endocannabinoid system.
“Manipulating the TRP channels in sensory neurons could provide much needed relief for patients who are suffering from chronic pain, asthma, urinary cystitis, or hearing loss,” explains Dr. Andrea Small-Howard, Chief Science Officer of GB Sciences. “The ability to use specific combinations of cannabinoids and terpenoids to modulate TRP ion channels in sensory neurons could usher in the beginning of a new era of precision medicines derived from the cannabis plant.”
Sensory neurons contain multiple members of the Transient Receptor Potential (TRP) ion channel family, where they detect pain, inflammation, stress, and noxious environmental signals and relay these signals through activation/de-activation of calcium, sodium, and magnesium ion gradients across cellular membranes. By studying the responses of cannabinoids and terpenoids both individually and in combinations at the level of individual receptors, GB Sciences has discovered reversible mechanisms that make personalized, precision medicines possible.
“GB Sciences remains committed to helping patients by supporting novel research programs that push the boundaries of what is known about the therapeutic potential of the diverse active ingredients in the cannabis plant,” said John Poss, CEO and Chairman of GB Sciences, Inc. “We are very fortunate to be working with accomplished university partners such as Dr. Helen Turner, Vice President of Innovation, Dean of Natural Sciences and Mathematics at Chaminade University, who has been instrumental in the discovery phase of our drug development program.”